tecovirimat will enhance the stage or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Tecovirimat is usually a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse outcomes if coadministered with sensitive substrates of those enzymes.
enasidenib will raise the amount or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Enasidenib (a weak CYP2C19 inhibitor) may possibly maximize systemic exposure of sensitive CYP2C19 substrates. Keep track of and change dose of substrate as clinically indicated.
Contact a Health care supplier straight away if you have any of these symptoms, particularly when they are new, worse, or worry you:
prednisone will decrease the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
You are alarmed by how often the seizures materialize, by how severe the seizure is, by just how long the seizure lasts, or by the colour or respiration of the individual.
Along with their valuable outcomes, most medicines click here can cause unwanted aspect-results While not Absolutely everyone ordeals them. The desk down below incorporates the most common kinds associated with diazepam.
Ought to a affected individual establish a dermatologic response although utilizing APTIOM, discontinue APTIOM use Except it truly is Obviously not drug related.
withdrawal reactions, together with seizures, that may be everyday living-threatening; use gradual taper when discontinuing therapy to scale back withdrawal reactions danger
eslicarbazepine acetate will improve the stage or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep an eye on.
danazol will increase the stage or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Stay clear of concomitant usage of tucatinib with CYP3A substrates, where small focus variations may result in significant or daily life-threatening toxicities. If unavoidable, lower CYP3A substrate dose In keeping with product labeling.
anastrozole will raise the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
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If symptom reduction not acquired following third administration, adjunctive therapy appropriate for the situation is usually recommended Discontinuation or dosage reduction